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Transplant Proc 31 (1999): s22-4, 4. Two recent trials have compared the clinical outcomes of intensive lipid lowering with atorvastatin 80 mg/day and standard lowering with pravastatin 40 mg/day. 1. Neurology 58 (2002): 1333-7, 48. Multi ingredient medications may also be listed when applicable. 3. Grundy SM "Can statins cause chronic low-grade myopathy?" J Urol 169 (2003): 613, 17. van Puijenbroek EP, Du Buf-Vereijken PW, Spooren PF, van Doormaal JJ "Possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil." Return to Pill Identifier… Results for "Simvastatin" (1 - 10 of 81) This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. I don't know if this is helpful, but simvastatin, lovastatin, and pravastatin are derived from fungi, and fluvastatin, atorvastatin, and rosuvastatin are entirely synthetic. Ann Pharmacother 30 (1996): 192, 3. There are different symptoms you may experience. There’s no easy way to tell if you have vasculitis beca… Statin intolerance occurs when a person develops side effects from statin use. Am J Med 94 (1993): 109-10, 31. Nakad A, Bataille L, Hamoir V, Sempoux C, Horsmans Y "Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin." Sinzinger H, Wolfram R, Peskar BA "Muscular side effects of statins." simvastatin 10 mg once daily. Padala KP, Padala PR, Potter JF "Simvastatin-induced decline in cognition." Ramdass MJ, Singh G, Andrews B "Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism." The nature of the rashes vary widely from simple macular skin discoloration to papular eruptions with and without itching. muscular pain, tenderness, wasting, or weakness, Blistering, peeling, or loosening of the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, weakness in the arms, hands, legs, or feet, excess air or gas in the stomach or intestines, feeling of constant movement of self or surroundings, pain or tenderness around the eyes and cheekbones, loss in sexual ability, desire, drive, or performance. Many organs and/or blood vessels are affected. Some forms are mild, others severe. Return to Pill Identifier…. "Summaries for patients. Am J Med 117 (2004): 823-9, 51. The patient was a 46-year-old female in no apparent distress. Am J Med 108 (2000): 351-2, 10. Peces R, Pobes A "Rhabdomyolysis associated with concurrent use of simvastatin and diltiazem." 57. Molden E, Andersson KS "Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients." ([2006 Dec]): 41. O 0, 23. Pedersen TR, Berg K, Cook TJ, Faergeman O, Haghfelt T, Kjekshus J, Miettinen T, Musliner TA, Olsson AG, Pyorala K, Thorgeirsso "Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the scandinavian simvastatin survival study." The rash started on the backs of her hands and quickly spread to her arms, trunk, neck, and face. Clin Cardiol 16 (1993): 317-22, 9. Galatti L, Polimeni G, Salvo F, Romani M, Sessa A, Spina E "Short-term memory loss associated with rosuvastatin." ChoquetKastylevsky G, Kanitakis J, Dumas V, Descotes J, Faure M, Claudy A "Eosinophilic fasciitis and simvastatin." Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: The more commonly reported adverse effects have included upper respiratory infection, headache, abdominal pain, constipation, and nausea. Curr Opin Lipidol 16 (2005): 640-7, 29. Gonyeau MJ "Statins and osteoporosis: a clinical review." Now I am also finding that certain brands of over-the-counter D3 break me out in a rash. See below for a comprehensive list of adverse effects. Here are a few reasons: 1. Ann Pharmacother (2007): 58. Common side effects include constipation, headaches, and nausea. Ann Pharmacother 40 (2006): 1880-3, 45. Chariot P, Abadia R, Agnus D, Danan C, Charpentier C, Gherardi RK "Simvastatin-induced rhabdomyolysis followed by a MELAS syndrome." Meier CR, Schlienger RG, Kraenzlin ME, Schlegel B, Jick H "HMG-CoA reductase inhibitors and the risk of fractures." A meta-analysis of large randomized clinical trials." The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The recommended dose range of simvastatin is 10 mg to 40 mg, and it is administered once daily in the evening with or without food. The rash spared the … Pharmacotherapy 26 (2006): 414-22, 42. Phan T, Mcleod JG, Pollard JD, Peiris O, Rohan A, Halpern JP "Peripheral neuropathy associated with simvastatin." Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. With therapy discontinuation or interruption, transaminase levels generally returned to pretreatment levels. Am J Med 87 (1989): s44-6, 30. Myalgia: Muscle pain which is experienced by 2% to 10% of people taking statins. SIMVASTATIN (SIM va stat in) is known as a HMG-CoA reductase inhibitor or 'statin'. 4. Muscle abnormalities in four patients taking statins to treat unfavorable cholesterol levels." Having to take more than one medication to treat your cholesterol, being 65 or older, and being female or having a small frame all can increase the likelihood for statin side effects. Some side effects may not be reported. Cerner Multum, Inc. "UK Summary of Product Characteristics." Postgrad Med J 83 (2007): 152-3, 25. And in the last 2 months I have had this itchy dry-like rash off and on. Ann Intern Med 137 (2002): 617-8, 27. Statins, an example of the most commonly prescribed medications to the elderly, are not without side effects. Lancet 344 (1994): 1383-9, 52. Arch Intern Med 152 (1992): 1093, 55. Last updated on Mar 4, 2020. Combo 'Polypill' May Cut Heart Attack, Stroke Risk Up to 40%, Computer 'Nudge' Spurs Doctors to Prescribe Statins to Heart Patients, We comply with the HONcode standard for trustworthy health information -. So simvastatin can cause eczema which is a form of chronic dermatitis (rash).Allergic reaction is one of the important causes of eczema. This was diagnosed by a dermotologist after doing a - Answered by a verified Dermatologist. I take 1 pill and wait 3 days to see if the rash re-appears. 5. reply #3. Certain people are at higher risk for developing side effects when taking lovastatin, simvastatin or pravastatin 2 3. Skin Rashes and Statins Although I do not as yet have an explanation for the mechanism involved, many cases of curious skin rashes are being reported from statin drug users. Dermatology 186 (1993): 248-52, 53. Even within a specific disease, the features differ among patients. 36. Available for Android and iOS devices. Newman TB, Hulley SB "Carcinogenicity of lipid-lowering drugs." In this report, we describe a case of a statin-induced eczematous dermatitis with a psoriasis-like clinical presentation and review the skin manifestations that may arise from statin thera… Zetia, atorvastatin, Jardiance, simvastatin, Brilinta, fenofibrate, Lopid, Xarelto, rosuvastatin, Lipitor. J Intern Med 240 (1996): 403-4, 18. If so, I wait 1-3 weeks until the rash goes away, and try a different type! Mauro VF, MacDonald JL "Simvastatin: a review of its pharmacology and clinical use." This drug may also reduce the risk of heart attack, stroke, or other health problems in patients with risk factors for heart or blood vessel disease. "Product Information. Kittiwake. Like any other medicine, metoprolol has some side effects, though most are quite rare and easily treatable. ... came out in hives about 3 weeks later, stopped taking never returned. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. If the rash is a new thing, then it seems unlikely to be the atorvastatin, unless you've changed maker recently. Simvastatin, sold under the brand name Zocor among others, is a lipid-lowering medication. I’m taking Allegra for the itch but it really doesn't help. JAMA 275 (1996): 55-60. Zocor (simvastatin)." Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Walker JF "Simvastatin: the clinical profile." Muldoon MF, Ryan CM, Sereika SM, Flory JD, Manuck SB "Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults." The incidence of myopathy with the 80 mg dose has been reported as disproportionately higher than that observed at lower doses and the risk of myopathy with simvastatin 80 mg/day is greater compared with other statins with similar or greater LDL-C lowering efficacy. Katznelson S "Effect of HMG-CoA reductase inhibitors on chronic allograft rejection." Any advice? More frequently reported side effects include: eczema and increased creatine phosphokinase in blood specimen. Check with your doctor immediately if any of the following side effects occur while taking simvastatin: Some side effects of simvastatin may occur that usually do not need medical attention. J Neurol Neurosurg Psychiatry 58 (1995): 625-8, 46. Patient did not recover after treatment with a topical corticosteroid. Pharmacotherapy 25 (2005): 228-43, 28. Multi ingredient medications may also be listed when applicable. South Med J 98 (2005): 827-9, 35. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Preparations: Tablets of 10/10, 10/20, 10/40, 10/80 mg. (ezetimibe/simvastatin) Prescribed for: Ezetimibe/simvastatin (Vytorin) is a combination of ezetimibe (Zetia) and simvastatin (Zocor) that is used for treating high levels of cholesterol in the blood. [Ref], Persistent elevations in transaminases of up to 3 times the upper limit of normal (3xULN) have been reported in 1% of patients. J Intern Med 240 (1996): 403-4. McDonagh J, Winocour P, Walker DJ "Musculoskeletal manifestations during simvastatin therapy." J Clin Endocrinol Metab 86 (2001): 4556-9, 34. Applies to simvastatin: oral suspension, oral tablet. Federman DG, Hussain F, Walters AB "Fatal rhabdomyolysis caused by lipid-lowering therapy." Some people develop a rash suddenly while other may go weeks or even months on a medication before experiencing problems. Are Statin Side Effects 'All in Your Head'? JAMA 292 (2004): 2585-90, 13. Almost any drug can cause a rash. Ann Pharmacother 36 (2002): 288-95, 24. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. View Comments (15) About the Author Joe Graedon. Stevens-Johnson syndrome sometimes starts with flu like symptoms and then erupts into a rash that also affects the mucous membranes of the body such as eyes, throat, mouth and genital area. DICP 25 (1991): 257-64, 39. J Am Geriatr Soc 54 (2006): 70-6, 47. South Med J 94 (2001): 1023-6, 16. We comply with the HONcode standard for trustworthy health information -. I felt itching in my throat and extreme itching on my face, along with a burning sensation. Orsi A, Sherman O, Woldeselassie "Simvastatin-associated memory loss." Gaist D, Jeppesen U, Andersen M, Garcia Rodriguez LA, Hallas J, Sindrup SH "Statins and risk of polyneuropathy: a case-control study." Graham DJ, Staffa JA, Shatin D, et al. Moreover, elderly patients are prone to pharmacologic interactions due to multiple medications. Br J Rheumatol 32 (1993): 647-8, 11. Medically reviewed by Drugs.com. It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. The rash went away with high doses of prednisone but it comes back as soon as I stop the prednisone. 19. Plosker GL, Mctavish D "Simvastatin - a reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia." Any incidence of hypersensitivity is unknown with these drugs. Cough 2. difficulty with swallowing 3. dizziness 4. fast heartbeat 5. fever 6. hives 7. itching 8. muscle cramps, pain, stiffness, swelling, or weakness 9. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue 10. skin rash 11. tightness in the chest 12. unusual tiredness or weakness 13. wheezing Arch Intern Med 161 (2001): 1456-7, 33. It can be a primary disease with an unknown cause. 6. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. A drug rash, sometimes called a drug eruption, is a reaction your skin can have to certain drugs. Gregoor PJ "Atorvastatin may cause nightmares." Alvarez JM, Rawdanowiz TJ, Goldstein J "Rhadbdomyolysis after coronary artery bypass grafting in a patient receiving simvastatin." Rash is a known side effect of Pravastatin. Finsterer J, Zuntner G "Rhabdomyolysis from Simvastatin triggered by infection and muscle exertion." It is taken by mouth. Manufacturers of statin drugs report the combined incidence of rash and allergic reactions to be 7.7% (data on file; Parke-Davis; Schaumburg, IL). Duits N, Bos FM "Depressive symptoms and cholesterol-lowering drugs." Dermatology 186 (1993): 272, 54. Definitely something to talk to your doctor about. Vytorin reduces total cholesterol and LDL cholesterol while it increases HDL cholesterol. Omar MA, Wilson JP "FDA adverse event reports on statin-associated rhabdomyolysis." Pedersen TR, Kjekshus J, Berg K, Haghfelt T, Faergeman O, Thorgeirsson G, Pyorala K, Miettinen T, Wilhelmsen L, Olsson AG, Wedel "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)." Ann Intern Med 137 (2002): I45, 6. Find patient medical information for Simvastatin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Instead, it refers to any sort of inflammation and/or discoloration that distorts the skin's normal appearance. My husband has been diagnosed with a rash caused by statin drugs. Vanpuijenbroek EP, Dubufvereijken PWG, Spooren PFMJ, Vandoormaal JJ "Possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil." Postgrad Med J 80 (2004): 551-2, 43. Statin myopathy generally takes one of three forms: 1. Simvastatin has been withdrawn and the rash resolved four weeks later. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. I have been on Simvastatin 20mg for 4 yrs; Metformin 500mg for 2 yrs, Ranitidine 150mg for 2yrs. J Thorac Cardiovasc Surg 116 (1998): 654-5, 32. Adverse Drug Reactions Advisory Committee (ADRAC) and the Adverse Drug Reactions Unit of the TGA "Australian Adverse Drug Reactions Bulletin. Rate this article 4.1-14 ratings. Chan MH, Mak TW, Chiu RW, Chow CC, Chan IH, Lam CW "Simvastatin increases serum osteocalcin concentration in patients treated for hypercholesterolaemia." Therapy usually is initiated with 10 or 20 mg daily, but individuals who have a high risk of heart disease can be started on 40 mg daily. Sundram F, Roberts P, Kennedy B, Pavord S "Thrombotic thrombocytopenic purpura associated with statin treatment." "Simvastatin causes changes in affective processes in elderly volunteers." Pharmacotherapy 27 (2007): 603-7, 36. The Principal Investigators." Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Diaczok BJ, Shali R "Statins unmasking a mitochondrial myopathy: a case report and proposed mechanism of disease." What makes treating vasculitisa challenge? Johnson JL, Loomis IB "A case of simvastatin-associated pancreatitis and review of statin-associated pancreatitis." J Cardiovasc Pharmacol 40 (2002): 163-71, 15. Bjerre LM, LeLorier J "Do statins cause cancer? Multiple sharply demarcated erythematous round patches with an overlying silvery scale were noted on the patient’s upper and lower extremities, trunk, buttocks, and back. Simons LA "Simvastatin in severe primary hypercholesterolemia: efficacy, safety, and tolerability in 595 patients over 18 weeks. Simvastatin (Zocor) works best if you take it in the evening since your body makes most of its cholesterol at night. Arch Intern Med 156 (1996): 2085-92, 12. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 34. A look at rash and pancreatitis as side effects of antidiabetic drugs A 67-year old woman with an extensive rash is referred urgently to hospital. Medicine 77 (1998): 378-83, 56. Am J Med 110 (2001): 716-23, 59. Weise WJ, Possidente CJ "Fatal rhabdomyolysis associated with simvastatin in a renal transplant patient."

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